MyBioSource.com's Anti-TKT Antibody, Rabbit Polyclonal is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: Immunocytochemistry, Immunofluorescence, and Western Blot. The Anti-TKT Antibody, Rabbit Polyclonal was generated using Tkt, and Transketolase as the antigen and it reacts with Human.
Description
Transketolase (TKT) is a thiamine pyrophosphate (vitamin B1)-dependent enzyme that links the pentose phosphate pathway with the glycolytic pathway by feeding excess sugar phosphates into the main carbohydrate metabolic pathways to generate biosynthetic reducing capacity in the form of NADPH as a substrate for ROS generation. TKT is a key enzyme of the pentose phosphate pathway (PPP), the Calvin cycle, and the ribulose monophosphate (RuMP) cycle. B. methanolicus MGA3 harbors two genes putatively coding for TKTs; one located on the chromosome (tkt(C)) and one located on the natural occurring plasmid pBM19 (tkt(P)). The metabolic enzyme TKT in the nonoxidative branch of the PPP regulates ribose 5-phosphate (R5P) levels and de novo nucleotide biosynthesis. TKT is required for maintaining cell proliferation in human liver cancer cell lines